Fazamorexant
Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research[1][2].
Product Specifications
CAS Number
[1808918-69-5]
Product Name Alternative
YZJ-1139
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fazamorexant.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=NC=CC=N2)C=CC(C)=C1)N3[C@]4([H])[C@@H](CC[C@@]3([H])CC4)COC5=CC=C(C=N5)F
Molecular Formula
C25H25FN4O2
Molecular Weight
432.49
References & Citations
[1]Zhang Y, et al. Asymmetric Synthesis of Nortropanes via Rh-Catalyzed Allylic Arylation. ACS Catal. 2022 Aug 5;12 (15) :8995-9002.|[2]Zhenya Zeng, et al. Development of a Scalable Route with Efficient Stereoisomer Control to YZJ-1139, an Orexin Receptor Antagonist. Org. Process Res. Dev. 2022, 26, 2, 447-457.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
E3778Hu-03 5x 96 Tests
Human Interleukin 1 Receptor like Protein 1, IL1RL1 ELISA KIT
Ask
View Details E3778Hu-04 10x 96 Tests
Human Interleukin 1 Receptor like Protein 1, IL1RL1 ELISA KIT
Ask
View Details MBS1176326-01 0.02 mg (E-Coli)
Recombinant Thermoanaerobacter sp. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr)
Ask
View Details MBS1176326-02 0.02 mg (Yeast)
Recombinant Thermoanaerobacter sp. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr)
Ask
View Details