Bcl-6 (Acetyl Lys379) rabbit pAb

Disease: A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with POU2AF1/OBF1. Disease: A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t (3;4) (q27;p11) with ARHH/TTF. Disease: Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t (3;14) (q27;q32); translocation t (3;22) (q27;q11) with immunoglobulin gene regions. function: Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. induction: Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan. PTM: Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway. similarity: Contains 1 BTB (POZ) domain. similarity: Contains 6 C2H2-type zinc fingers. subunit: Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9. tissue specificity: Expressed in germinal center T and B cells and in primary immature dendritic cells.