Lomustine

Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.

Product Specifications

CAS Number

[13010-47-4]

Product Name Alternative

CCNU; NSC 79037

UNSPSC

12352211

Hazard Statement

H301, H350

Target

Apoptosis; Autophagy; DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Lomustine.html

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1CCCCC1)N(CCCl)N=O

Molecular Formula

C9H16ClN3O2

Molecular Weight

233.70

Precautions

H301, H350

References & Citations

[1]Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13 (11) :2353-2361.|[2]Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122 (3) :547-56.|[3]Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18 (10) :1390-401.