Lomustine
Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.
Product Specifications
CAS Number
13010-47-4
Product Name Alternative
CCNU; NSC 79037
UNSPSC
12352211
Hazard Statement
H301, H350
Target
Apoptosis; Autophagy; DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Lomustine.html
Purity
99.90
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1CCCCC1)N(CCCl)N=O
Molecular Formula
C9H16ClN3O2
Molecular Weight
233.70
Precautions
H301, H350
References & Citations
[1]Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13 (11) :2353-2361.|[2]Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122 (3) :547-56.|[3]Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18 (10) :1390-401.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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