Dienogest

Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia[1][2].

Product Specifications

CAS Number

[65928-58-7]

Product Name Alternative

STS 557

UNSPSC

12352211

Hazard Statement

H361

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Dienogest.html

Purity

99.93

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](O)(CC#N)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3CC2)=O

Molecular Formula

C20H25NO2

Molecular Weight

311.42

Precautions

H361

References & Citations

[1]Shimizu Y, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids. 2011 Jan;76 (1-2) :60-7. |[2]Katayama H, et al. Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model. Hum Reprod. 2010 Nov;25 (11) :2851-8.