Telotristat etiprate
Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
Product Specifications
CAS Number
1137608-69-5
Product Name Alternative
LX1606 (Hippurate)
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/LX1606-Hippurate.html
Purity
99.89
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C([C@H](CC1=CC=C(C=C1)C2=CC(O[C@H](C3=C(C=C(C=C3)Cl)N4C=CC(C)=N4)C(F)(F)F)=NC(N)=N2)N)OCC.O=C(C5=CC=CC=C5)NCC(O)=O
Molecular Formula
C36H35ClF3N7O6
Molecular Weight
754.15
Precautions
H302, H312, H332
References & Citations
[1]Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.|[2]Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
MBio. 2025 Aug 13;16 (8) :e0097625.|Ecotoxicol Environ Saf. 2025 Jan 22:290:117764.|Microb Biotechnol. 2025 Nov;18 (11) :e70257.|Nutrients. 2021 Dec 28;14 (1) :117.
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