Telotristat etiprate

Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Product Specifications

CAS Number

[1137608-69-5]

Product Name Alternative

LX1606 (Hippurate)

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/LX1606-Hippurate.html

Purity

99.89

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C([C@H](CC1=CC=C(C=C1)C2=CC(O[C@H](C3=C(C=C(C=C3)Cl)N4C=CC(C)=N4)C(F)(F)F)=NC(N)=N2)N)OCC.O=C(C5=CC=CC=C5)NCC(O)=O

Molecular Formula

C36H35ClF3N7O6

Molecular Weight

754.15

Precautions

H302, H312, H332

References & Citations

[1]Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.|[2]Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

MBio. 2025 Aug 13;16 (8) :e0097625.|Ecotoxicol Environ Saf. 2025 Jan 22:290:117764.|Microb Biotechnol. 2025 Nov;18 (11) :e70257.|Nutrients. 2021 Dec 28;14 (1) :117.