Polystyrene A Sulfonyl Chloride

This polymer bound alkylsulfonyl chloride resin is an equivalent to alkyl sulfonic chloride and can be used in numerous applications. When this resin is treated with nucleophiles, a variety of polymer bound sulfonates can be created (e.g. sulfonyl azides, sulfonyl hydrazine) and subsequently used as polymeric supports, polymer bound reagents or in catalytic organic synthesis. Application in the "catch and release" strategy, where the resin catches a compound to form a polymer bound tosylate. Purifying the polymer bound tosylate by washing and subsequent treatment by a nucleophile, releases the target product from the resin. A typical application is to form polymer bound tosylates by loading alcohols to the resin. Treatment with nucleophiles like amines, imidazoles or thiols generates the corresponding sec. or tert. amines, alkylimidazoles or thioethers. This resin can also be used as a scavenger for amines, hydrazines and other nucleophiles.