HypoGel® 400 REM

HypoGel® is a novel hydrophilic Gel® type resin which combines high capacities with good solvent compatibility. Glycol spacers with n = 5 or 10 EO units separate the reactive sites from the polystyrene matrix and modify the hydrophobic properties of the polystyrene backbone. Due to the spacer effect the functional group shows a higher mobility which results in higher kinetic rates and high resolution NMR spectra from immobilized compounds on the bead. The resin is compatible to a wide range of solvents and in contrast to polystyrene even polar solvents like methanol or ethanol can be used. These resins show high loading and a hydrophilicity between polystyrene and TentaGel®. REM resin for a broad range of solvents. This resin with the immobilized acrylic acid is a support for the SOPS of tertiary amines. The first step is a Michael addition of a primary or secondary amine followed by quarternization with the appropriate alkyl halide. β-Elimination yields the tertiary amine. In this resin the glycol spacer contains 10 EO units which separate the reactive sites from the polystyrene matrix.