TentaGel® S PAL

TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. The graft copolymer shows modified physicochemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix) and has hydrophobic and hydrophilic properties. These copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da. TentaGel® resins have high diffusion rates and excellent swelling in a wide range of solvents from e.g. toluene to water. TentaGel® S is a standard resin for a large number of applications, useful in batch and flow through systems. The resin shows an increased swelling volume and a significant lower loading. In this resin the acid sensitive 5- (4-aminomethyl-3,5-dimethoxy-phenoxy) valeric acid linker is attached to amino TentaGel® R. After completion of the peptide synthesis treatment with 95% TFA liberates the desired peptide amide. Comparison studies have shown that the acid sensitivity of the PAL linker is approximately twice compared to Rink resin.