Polystyrene Dawson MeDbz RAM Resin

This resin contains the Dawson MeDbz Rink Amide linker attached to aminomethylated polystyrene. It is a new type of support for the synthesis of C-terminal peptide aryl thioesters by Fmoc SPPS. When peptide assembly is finished in a follow up reaction a cyclic N-acylurea is formed which can either be converted to the desired aryl thioester by aryl thiol or directly used in native chemical ligation without prior isolation of the intermediate precursor.