TentaGel® M RAM

TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. The graft copolymer shows modified physicochemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix) and has hydrophobic and hydrophilic properties. These copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da. TentaGel® resins have high diffusion rates and excellent swelling in a wide range of solvents from e.g. toluene to water. The narrow particle size distribution of this TentaGel® microparticles is lot-dependent. The main particle size of an individual lot will be in a size window between 8 and 12 µm. The particle size distribution for each individual lot is +/-10% from the main size of this lot or less. This resin is functionalized with a modified Rink amide linker and is ideal for the Fmoc SPPS of peptide amides. Cleavage from this support is achieved with 95% TFA to give peptide amides. The microspherical shape and the narrow particle size distribution of this resin allow applications in automated sorters, for creating huge libraries, high speed synthesis etc.