TentaGel® AC RAM

TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. The graft copolymer shows modified physicochemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix) and has hydrophobic and hydrophilic properties. These copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da. TentaGel® resins have high diffusion rates and excellent swelling in a wide range of solvents from e.g. toluene to water. The resins contain 5-10% non cleavable covalently attached ligands, 40 - 45% linker for peptide amide release at low concentrated TFA (5%) and 40 - 45% linker for peptide amide release with 95% TFA. The peptide, liberated by 5% TFA treatment must be separated from the resin and deprotected with 95% TFA in a follow up step. This resin type is designed for screening of peptide amide libraries by sequential release.