Magnetic Polystyrene AM NH₂

Magnetic beads are well established for magnetic separation processes like protein purification, RNA and DNA extraction, immunoprecipitation but also in NGS and PCR applications. We have developed a new type of polymeric magnetic beads to expand the space of resins used in solid phase organic synthesis. The novel magnetic beads are based on polystyrene beads where the magnetic core is imbedded into a low crosslinked polystyrene matrix. All properties known from traditional polystyrene resins used in solid phase organic synthesis (SPOS) like swelling and shrinking in organic solvents are still the same. Applying the novel magnetic beads in a multistep parallel automated synthesis system, the separation of the beads from the reaction mixture is performed by simply applying an external magnetic field which fixes the resin reversible on the bottom of the reaction vessels. The separated supernatant can easily be removed by aspiration. Several reaction types like amide couplings, nucleophilic aromatic substitution and Suzuki-Miyaura reactions were successfully performed in a parallel synthesis approach on micromole scale.