Trabodenoson
Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma[1].
Product Specifications
CAS Number
871108-05-3
Product Name Alternative
INO-8875
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/trabodenoson.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O[C@H](CO[N+]([O-])=O)[C@H]1O)N2C3=NC=NC(NC4CCCC4)=C3N=C2
Molecular Formula
C15H20N6O6
Molecular Weight
380.36
Precautions
H315, H319, H335
References & Citations
[1]Guorong Li, et al. Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. Invest Ophthalmol Vis Sci. 2018 Jan 1;59 (1) :383-392.|[2]Yan Guo, et al. Topical Trabodenoson Is Neuroprotective in a Rodent Model of Anterior Ischemic Optic Neuropathy (rNAION) . Transl Vis Sci Technol. 2019 Dec 20;8 (6) :47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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