(3S,4R) -ME-344
Product Specifications
CAS Number
1374524-84-1
Target
Mitochondrial Metabolism, ROS
Related Pathways
Metabolism, Immunology/Inflammation
Bioactivity
(3S,4R) -ME-344 is the (3S,4R) -enantiomer of ME-344. As an inhibitor of mitochondrial heme oxygenase 1 (HO-1), ME-344 specifically binds to and alters the structure of HO-1, facilitating its translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells like H460 and SHP-77. This compound reduces mitochondrial ATP production and induces reactive oxygen species (ROS), disrupting redox balance and mitochondrial function. ME-344 exhibits significant antitumor activity, making it useful in cancer research, such as for breast cancer.
Smiles
CC1=C2C([C@H]([C@H](CO2)C3=CC=C(O)C=C3)C4=CC=C(O)C=C4)=CC=C1O
Molecular Formula
C22H20O4
Molecular Weight
348.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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