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(R, R) -VRT-534

Product Specifications

CAS Number

926664-33-7

Target

Gap Junction Protein

Related Pathways

Cytoskeletal Signaling

Bioactivity

(R, R) -VRT-534 is the (R, R) -enantiomer of VRT-534. VRT-534 (Compound 3) acts as a chemical chaperone targeting connexin 26 (Cx26) . VRT-534 demonstrates dose-dependent binding with recombinant WT Cx26 and mutant Cx26 K188N, with EC50 values of 19 μM and 5 μM, respectively. VRT-534 is applicable in research related to hearing impairments.

Smiles

C(NC=1SC([C@@H](C2=C(Cl)C=CC=C2)N3C[C@H](O)CC3)=CN1)(=O)C4(CC4)C=5C=C6C(=CC5)OCO6

Molecular Formula

C25H24ClN3O4S

Molecular Weight

497.99

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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