(R, R) -VRT-534
Product Specifications
CAS Number
926664-33-7
Target
Gap Junction Protein
Related Pathways
Cytoskeletal Signaling
Bioactivity
(R, R) -VRT-534 is the (R, R) -enantiomer of VRT-534. VRT-534 (Compound 3) acts as a chemical chaperone targeting connexin 26 (Cx26) . VRT-534 demonstrates dose-dependent binding with recombinant WT Cx26 and mutant Cx26 K188N, with EC50 values of 19 ?M and 5 ?M, respectively. VRT-534 is applicable in research related to hearing impairments.
Smiles
C(NC=1SC([C@@H](C2=C(Cl)C=CC=C2)N3C[C@H](O)CC3)=CN1)(=O)C4(CC4)C=5C=C6C(=CC5)OCO6
Molecular Formula
C25H24ClN3O4S
Molecular Weight
497.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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