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(S) -Padsevonil

Product Specifications

CAS Number

1294001-37-8

Target

GABA Receptor

Related Pathways

Membrane transporter/Ion channel, Neuroscience

Bioactivity

(S) -Padsevonil is the S-enantiomer of Padsevonil. Padsevonil (UCB0942) is a potent antiepileptic agent that selectively targets both presynaptic and postsynaptic sites. It binds with high affinity to synaptic vesicle protein 2 (SV2) and acts as a positive allosteric modulator and partial agonist of GABAAR, showing greater efficacy on receptors containing α1 and α5 subunits. Padsevonil demonstrates antiepileptic effects in various rodent models.

Smiles

C(C=1N2C(=NC1C(F)(F)F)SC(COC)=N2)N3C[C@H](CC(Cl)(F)F)CC3=O

Molecular Formula

C14H14ClF5N4O2S

Molecular Weight

432.8

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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