2'-RIBOTAC-U recruiter-linker

The compound 2'-RIBOTAC-U recruiter-linker (Compound 9) is composed of an RNase L recruiter and a linker. It reacts via copper-catalyzed click chemistry with either 2’-azido-uridine or 5’-azidomethyl-uridine to form 2'-RIBOTAC-U and 5'-RIBOTAC-U, respectively. Notably, 2'-RIBOTAC-U exhibits activity against SARS-CoV-2.