(Rac) -Vepdegestrant
Product Specifications
CAS Number
2229711-08-2
Target
Estrogen Receptor/ERR, PROTACs
Related Pathways
Endocrinology/Hormones, PROTAC
Bioactivity
(Rac) -Vepdegestrant is an isomer of Vepdegestrant. Vepdegestrant ((Rac) -ARV-471) is an orally active estrogen receptor PROTAC degrader used against breast cancer. It is a heterobifunctional molecule that facilitates the interaction between estrogen receptor α and the intracellular E3 ligase complex. Vepdegestrant induces ubiquitination and subsequent degradation of the estrogen receptor via the proteasome, effectively degrading ER in ER-positive breast cancer cell lines with a DC50 value of approximately 2 nM.
Smiles
OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)C9C(=O)NC(=O)CC9)CC5)=CC1
Molecular Formula
C45H49N5O4
Molecular Weight
723.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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