(S, R, S) -MI-1061
Product Specifications
CAS Number
1410738-90-7
Target
Drug-Linker Conjugates for ADC, MDM-2/p53
Related Pathways
Apoptosis, Antibody-drug Conjugate/ADC Related
Bioactivity
(S, R, S) -MI-1061 is an isomer of MI-1061. It serves as a precursor for synthesizing Antibody-Drug Conjugates (ADCs) . MI-1061 acts as a potent, orally bioavailable, and chemically stable inhibitor of MDM2 (MDM2-p53 interaction) with IC50=4.4 nM and Ki=0.16 nM. This compound activates p53 and induces apoptosis in murine SJSA-1 xenograft tissues, exhibiting antitumor properties.
Smiles
O=C1[C@]2(C3(N[C@H](C(NC4=CC=C(C(O)=O)C=C4)=O)[C@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
Molecular Formula
C30H26Cl2FN3O4
Molecular Weight
582.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7014035-01 0.02 mg
Recombinant Pseudomonas fluorescens Disulfide bond formation protein B 1 (dsbB1)
Sign In for Pricing
View Details MBS7014035-02 0.1 mg
Recombinant Pseudomonas fluorescens Disulfide bond formation protein B 1 (dsbB1)
Sign In for Pricing
View Details MBS7014035-03 5x 0.1 mg
Recombinant Pseudomonas fluorescens Disulfide bond formation protein B 1 (dsbB1)
Sign In for Pricing
View Details 
A73877-050 50 µL
Histone H1.0 Recombinant Monoclonal Antibody [1C7]
Sign In for Pricing
View Details K1339505 3x 1.0 µg
MRS2P1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
Sign In for Pricing
View Details