Di-DTPA-LTL

Di-DTPA-LTL is a divalent hapten designed based on tyrosine-containing polypeptides. It exhibits excellent hydrophilicity and biodistribution properties. di-DTPA-LTL is labeled with 111In (indium) and 131I (iodine) . By administering a fixed low dose (5 mg) of a bispecific antibody (anti-CEA x, anti-DTPA) and the di-DTPA hapten peptide (labeled with 111In) to patients, di-DTPA-LTL enables tumor radioimmunoimaging in patients with primary colorectal cancer expressing CEA.