T-Boc-N-amido-PEG4-Val-Cit
Product Specifications
CAS Number
2231240-82-5
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
T-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.
Smiles
[C@H](C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)(NC(CCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O)[C@@H](C)C
Molecular Formula
C27H51N5O11
Molecular Weight
621.721
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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