Fmoc-PEG4-Val-Cit-PAB-OH
Product Specifications
CAS Number
2055024-58-1
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that incorporates a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be used to attach reactive groups (such as PNP) for drug payload conjugation. The Fmoc protecting group can be removed with piperidine to expose a primary amine, facilitating amide bond formation. Val-Cit-PAB is cleaved by cellular proteases to efficiently release the payload inside cells.
Smiles
C(OC(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)[C@H](C)C)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3
Molecular Formula
C44H60N6O11
Molecular Weight
848.981
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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