Fmoc-PEG2-Val-Cit-PAB-OH
Product Specifications
CAS Number
2055024-59-2
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.
Smiles
C(OC(NCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)[C@@H](C)C)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3
Molecular Formula
C40H52N6O9
Molecular Weight
760.876
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PA1850 200 Vials
Starch Iodide Paper (10 Books of 20 Leaves in Box)
Sign In for Pricing
View Details 
043440-HRP 200 µL
TTLL4, ID (TTLL4, KIAA0173, Tubulin polyglutamylase TTLL4, Tubulin-tyrosine ligase-like protein 4) (Azide free) (HRP) discontinued
Sign In for Pricing
View Details