Bis-sulfone-PEG8-NHS ester
Product Specifications
CAS Number
2363757-66-6
Bioactivity
Bis-sulfone-PEG8-NHS ester is a bis-alkylating labeling agent that selectively removes cysteine sulfur atoms from native disulfide bonds. These agents achieve bis-alkylation by covalently bridging the two thiols from cysteine residues derived from reduced native disulfide bonds, such as interchain disulfide bonds in antibodies, through a three-carbon bridge while maintaining the integrity of the protein structure. The hydrophilic PEG spacer enhances solubility in aqueous media.
Smiles
O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C2=CC=C(C=C2)C(=O)C(CS(=O)(=O)C3=CC=C(C=C3)C)CS(=O)(=O)C4=CC=C(C=C4)C
Molecular Formula
C48H64N2O18S2
Molecular Weight
1021.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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