Boc-PEG4-Val-Cit-PAB-OH
Product Specifications
CAS Number
2055024-54-7
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB is useful for attaching reactive groups (e.g., PNP) to bind with drug payloads. Acidic conditions can remove the Boc protecting group, exposing the primary amine for conjugation reactions to form amides. The Val-Cit-PAB segment can be cleaved by intracellular proteases, allowing efficient payload release within cells.
Smiles
N(C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C1=CC=C(CO)C=C1
Molecular Formula
C34H58N6O11
Molecular Weight
726.858
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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