Azido-PEG8-Amido-Val-Cit-PAB
Product Specifications
CAS Number
2356229-77-9
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker efficiently cleaved by cathepsin B. Since cathepsin B is localized in lysosomes, the ADC payload is released exclusively within cells. The azido group reacts with DBCO, BCN, or other alkyne groups through click chemistry. The PEG spacer enhances water solubility. Reagent grade, intended for research purposes.
Smiles
N(C([C@@H](NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C1=CC=C(CO)C=C1
Molecular Formula
C40H69N9O15
Molecular Weight
916.027
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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