2',3'-Cyclic NADP disodium

2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundantly found in the myelin. It is utilized in coupled enzyme assays for the quantification of CNP activity. At a concentration of 5 μM, 2',3'-cNADP disodium can enhance calcium release due to calcium overload and prevent calcium-induced swelling in rat brain mitochondria.

O[C@H]([C@@H]1O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O[C@@H]1COP(OP(OC[C@H]3O[C@@H](N4C5=NC=NC(N)=C5N=C4)[C@@]6([H])[C@]3([H])OP([O-])(O6)=O)([O-])=O)([O-])=O.[Na+].[Na+]