AL284
AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes[1].
Product Specifications
CAS Number
[2270876-07-6]
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/al284.html
Smiles
CCN1CCN(CC1)C2CCN(CC2)C(COC3=CC=C(C=C3)C4=CC=C(C=C4)OC)=O
Molecular Formula
C26H35N3O3
Molecular Weight
437.57
References & Citations
[1]Kumari R, et al. Enzyme Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes. ACS Infect Dis. 2024 Oct 11;10 (10) :3664-3680.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Curated Selection
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