AL284

AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes[1].

Product Specifications

CAS Number

[2270876-07-6]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/al284.html

Smiles

CCN1CCN(CC1)C2CCN(CC2)C(COC3=CC=C(C=C3)C4=CC=C(C=C4)OC)=O

Molecular Formula

C26H35N3O3

Molecular Weight

437.57

References & Citations

[1]Kumari R, et al. Enzyme Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes. ACS Infect Dis. 2024 Oct 11;10 (10) :3664-3680.