Endonuclease IV

Endonuclease IV is an apurinic/apyrimidinic (AP) endonuclease that functions as a DNA repair enzyme. It exhibits endonuclease activity at AP sites, possesses 3' phosphodiesterase activity (allowing it to remove various blocking lesions at the 3' end of DNA), and demonstrates endonuclease activity against oxidative DNA damage, as well as 3' to 5' exonuclease activity.