YIGSR-Lys (N3)
Product Specifications
CAS Number
2415188-59-7
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Bioactivity
YIGSR-Lys (N3) is a peptide that inhibits the tumor growth and metastasis of leukemia cells. This compound interferes with the interaction between cells and laminin I by blocking a 67 kDa laminin-binding protein, thereby reducing shear-induced eNOS expression in laminin cells. As a click chemistry reagent, YIGSR-Lys (N3) contains an azide group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkynyl-containing molecules. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with molecules bearing DBCO or BCN groups.
Smiles
[C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)N)=O)[C@H](CC)C)=O)=O)CO)=O)(C(N[C@@H](CCCCN=[N+]=[N-])C(O)=O)=O)CCCNC(=N)N
Molecular Formula
C32H52N12O9
Molecular Weight
748.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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