TRAP-14 amide

Product Specifications

CAS Number

141923-36-6

Target

Protease-activated Receptor|||MMP|||Integrin

Related Pathways

Cytoskeletal Signaling|||GPCR/G Protein|||Proteases/Proteasome

Bioactivity

TRAP-14 amide is a protease-activated receptor (PAR) activating peptide and acts as a PAR agonist, with an EC50 of 24 ?M. It induces significant platelet aggregation via ADP and MMP-2 dependent pathways and is insensitive to Aspirin. Additionally, TRAP-14 amide effectively increases the surface expression of glycoprotein (GP) Ib and GPIIb/IIIa, as well as the release of ADP.

Smiles

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