Hydrostatin-TL1

Product Specifications

CAS Number

2243975-43-9

Target

Interleukin|||ERK|||Integrin|||JNK|||NF-?B|||p38 MAPK|||TNF

Related Pathways

Immunology/Inflammation|||Cytoskeletal Signaling|||MAPK|||NF-?B|||Apoptosis

Bioactivity

Hydrostatin-TL1 (H-TL1) is a nonapeptide that acts as a TNF-? antagonist. This compound can be isolated from the venom glands of the sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-? and TNFR1, thus reducing TNF-? cytotoxicity and inflammatory responses. It is applicable for research into TNF-?-related inflammatory diseases such as rheumatoid arthritis, osteoporosis, and inflammatory bowel disease (IBD) .

Smiles

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