β-catenin inhibitory peptoid
Product Specifications
CAS Number
2579070-02-1
Target
Androgen Receptor|||Wnt/beta-catenin
Related Pathways
Endocrinology/Hormones|||Cytoskeletal Signaling|||Stem Cells
Bioactivity
?-catenin inhibitory peptoid (compound 13) disrupts the interaction between ?-catenin and TCF with an IC50 of 5.44 µM. It inhibits Wnt signaling in prostate cancer cell lines (IC50 = 0.105 µM) and androgen receptor (AR) signaling (IC50 = 1.02 µM) . This compound significantly reduces cell proliferation in prostate cancer cell lines.
Smiles
O=C1N(CC(=O)N(CCCOC(C)C)CC(=O)N([C@@H](C)C2=CC=C(OC)C=C2)CC(=O)N([C@@H](C)C3=CC=C(OC)C=C3)CC(=O)N[C@H](C)C(=O)N(CCC4=C(OC5=CC=CC=C5)C=CC=C4)C1)C6=CC(OC)=CC(OC)=C6
Molecular Formula
C59H72N6O12
Molecular Weight
1057.24
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/390881189072257057/TP3692
Available Sizes
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