β-catenin inhibitory peptoid

Product Specifications

CAS Number

2579070-02-1

Target

Androgen Receptor|||Wnt/beta-catenin

Related Pathways

Endocrinology/Hormones|||Cytoskeletal Signaling|||Stem Cells

Bioactivity

?-catenin inhibitory peptoid (compound 13) disrupts the interaction between ?-catenin and TCF with an IC50 of 5.44 µM. It inhibits Wnt signaling in prostate cancer cell lines (IC50 = 0.105 µM) and androgen receptor (AR) signaling (IC50 = 1.02 µM) . This compound significantly reduces cell proliferation in prostate cancer cell lines.

Smiles

O=C1N(CC(=O)N(CCCOC(C)C)CC(=O)N([C@@H](C)C2=CC=C(OC)C=C2)CC(=O)N([C@@H](C)C3=CC=C(OC)C=C3)CC(=O)N[C@H](C)C(=O)N(CCC4=C(OC5=CC=CC=C5)C=CC=C4)C1)C6=CC(OC)=CC(OC)=C6