β-catenin inhibitory peptoid

?-catenin inhibitory peptoid (compound 13) disrupts the interaction between ?-catenin and TCF with an IC50 of 5.44 µM. It inhibits Wnt signaling in prostate cancer cell lines (IC50 = 0.105 µM) and androgen receptor (AR) signaling (IC50 = 1.02 µM) . This compound significantly reduces cell proliferation in prostate cancer cell lines.

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