CGN peptide

CGN peptide is a polypeptide composed of 13 D-amino acids, abbreviated as CGN peptide. It is the retro-inverso isomer of the L-peptide TGN (TGNYKALHPHNG), capable of targeting siRNA delivery to the blood-brain barrier (BBB) . d (CGNHPHLAKYNGT) can be utilized in Alzheimer's disease (AD) research.

C([C@@H](CC1=CN=CN1)NC([C@H](NC(CNC([C@@H](CS)N)=O)=O)CC(N)=O)=O)(=O)N2[C@@H](C(N[C@H](CC3=CN=CN3)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC4=CC=C(O)C=C4)C(N[C@@H](C(NCC(N[C@H]([C@H](C)O)C(O)=O)=O)=O)CC(N)=O)=O)=O)CCCCN)=O)C)=O)CC(C)C)=O)=O)CCC2