Ac-DMLD-CMK
Product Specifications
CAS Number
2588354-33-8
Target
Caspase|||Pyroptosis
Related Pathways
Proteases/Proteasome|||Immunology/Inflammation|||Apoptosis
Bioactivity
Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.
Smiles
[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)(NC([C@@H](NC([C@H](CC(O)=O)NC(C)=O)=O)CCSC)=O)CC(C)C
Molecular Formula
C22H35ClN4O9S
Molecular Weight
567.053
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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