Ac-MRGDH-NH2
Product Specifications
Target
Integrin
Related Pathways
Cytoskeletal Signaling
Bioactivity
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru (Ph2phen) 2 (κS, κN- (Ac-MRGDH-NH2) ) ]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru (Ph2phen) 2 (OH2) 2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.
Smiles
CC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N
Molecular Formula
C25H41N11O8S
Molecular Weight
655.727
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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