RI-OR2-TAT

RI-OR2-TAT is a brain-penetrable inhibitor targeting ?-amyloid (?-Amyloid) oligomerization. It is engineered by integrating the HIV protein transduction domain TAT into RI-OR2. RI-OR2-TAT binds to A?42 fibrils with a Kd value of 58-125 nM. It reduces A? aggregation and plaque levels, diminishes microglial activation and oxidative damage, and enhances the number of young neurons in the dentate gyrus.

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