MOTS-c, mouse

MOTS-c, mouse is a mitochondrial-derived peptide involved in the regulation of pancreatic cell function. It reduces insulin secretion and expression in INS-1E cells while enhancing glucagon secretion and expression in ?TC-1 cells. Additionally, MOTS-c, mouse decreases apoptosis in both INS-1E and ?TC-1 cells and counteracts diet-induced obesity and insulin resistance by activating AMPK.