VGB3
Product Specifications
Target
Apoptosis, Akt, VEGFR, mTOR, ERK, PI3K
Related Pathways
PI3K/Akt/mTOR signaling, Angiogenesis, Cytoskeletal Signaling, MAPK, Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
VGB3 is a peptide antagonist of vascular endothelial growth factor receptor 1 (VEGFR1) and VEGFR2, exhibiting anti-angiogenic and anti-tumor properties. It binds to VEGFR1 and VEGFR2, thereby inhibiting VEGF-driven endothelial cell proliferation, migration, and tube formation, as well as suppressing tumor growth and metastasis in a mouse 4T1 breast cancer model.
Molecular Formula
C67H101N19O21S2
Molecular Weight
1572.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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