Microcin J25

Microcin J25 (MccJ25) is a cyclopeptide antibiotic made up of 21 unmodified amino acid residues. It effectively inhibits the DNA-dependent RNA polymerase (RNAP) of Gram-negative bacteria and exhibits antibacterial activity.

O=C1N2[C@](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC3=CC=C(O)C=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@]([C@@H](C)O)(C(=O)N5[C@@](CCC5)(C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CO)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC=C(O)C=C7)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC8=CN=CN8)C(=O)N[C@H]1C(C)C)[H])[H])[H])[H])(CCC2)[H]