DN59

DN59 is a peptide composed of 33 amino acids that mimics the stem region of the dengue virus type 2 E protein. It is capable of inhibiting all four serotypes of the dengue virus (IC50: 2-5 μM) as well as other flaviviruses. DN59 exerts its antiviral activity by interacting directly with viral particles, leading to the release of genomic RNA.

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