α-Dendrotoxin

α-Dendrotoxin (α-DTX) is a small molecular peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps) . This compound acts as a blocker for KV1.1, KV1.2, KV1.6, and ASIC channels. By inhibiting potassium channels, α-Dendrotoxin reduces the threshold for neuronal action potentials and increases the frequency of these potentials, thereby enhancing neuronal excitability. It is utilized in neurotoxicological research.