HIV gp120 (318-327)

HIVgp120 (318-327) is a short sequence (rgpgrafvti) from the envelope peptide of the HIV-1 IIIB strain, corresponding to the conserved C-terminal region of the glycoprotein. It is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIVgp120 (318-327) lacks the A2 anchor residues needed for epitope-specific CTL recognition but possesses structural features that allow mixed A2 binding.

C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(O)=O)=O)[C@@H](C)O)=O)[C@@H](C)C)=O)=O)C)=O)CCCNC(=N)N)=O)(=O)[C@H]2N(C(CNC([C@H](CCCNC(=N)N)N)=O)=O)CCC2