TCL1 (10-24)

Product Specifications

CAS Number

835655-37-3

Target

Apoptosis|||Akt

Related Pathways

Apoptosis|||PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling

Bioactivity

TCL1 (10-24) is an Akt inhibitor encompassing the betaA strand of human TCL1. It interacts with the Akt PH domain, preventing phosphoinositide binding and thereby inhibiting membrane translocation and activation of Akt. TCL1 (10-24) inhibits cellular proliferation and anti-apoptosis, demonstrating its capacity to suppress tumor growth in vivo [1].

Smiles

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