SPSB2-iNOS inhibitory cyclic peptide-2

Compound CP2, also known as SPSB2-iNOS inhibitory cyclic peptide-2, serves as an inhibitor disrupting the interaction between SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS. It binds to the SPSB2 on the iNOS site with an affinity (K D) of 21 nM. This peptide is characterized by its resistance to reduction and oxidative stability [1].

C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCC(=O)N3)[H]