SPSB2-iNOS inhibitory cyclic peptide-1

SPSB2-iNOS inhibitory cyclic peptide-1, an inhibitor for the interaction between the SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, binds SPSB2 at the iNOS site with a K D of 4.4 nM. It is resistant to proteases pepsin, trypsin, and ?-chymotrypsin and remains stable in human plasma and oxidative environments [1].

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